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Yeh W, Tsai C, Ko J, Yang H (2020) Hylocereus polyrhizus peel extract retards alcoholic liver disease progression by modulating oxidative stress and inflammatory responses in C57BL/6 mice
Mechanistically, ADP-ribosyl-transferase 2 (ART2) transfers the ADP-ribose moiety from NAD + to the neighbouring cell surface purinergic P2 7 receptor (P2 7R), thereby initiating the apoptotic programme, characterized by deregulated calcium flux, pore formation, phosphatidylserine exposure, shedding of CD62L and cell shrinkage, and hence inducing cell death in peripheral T cells exposed to NAD + [103]

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doi: 10.3389/fphar.2018.01253
doi: 10.1016/j.joca.2004.12.006