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JAMA Network Open , 6(11), e2342210

Stress management Chronic psychological stress activates the hypothalamic-pituitary-adrenal (HPA) axis, producing cortisol that initially suppresses inflammation but eventually leads to cortisol resistance and a paradoxical increase in inflammatory signaling

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Reznikov LR, Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y, Du J, Hildebrand MS, Smith RJ, Randak CO, et al