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To further assess the reduced survival associated with CINPA1, liver and blood samples were collected 24h after sham or CLP surgery ( Figure 6C )

Classical antifolate drugs, including methotrexate (targeting DHFR) [153] and fluoropyrimidine agents (targeting TYMS) [154], induce cell death in rapidly proliferating malignancies by specifically inhibiting key enzymes in 1 C metabolism, thereby depleting nucleotide pools and causing replication stress [101]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Fasano A

doi: 10.1002/ajh.24088

Peptides of legumes and grains have been reported to possess anti-inflammatory activity (36) that through modulation of the inflammatory pathways limit the recruitment of neutrophils to injury sites