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Oncogene 21 : 82408250 Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

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In preclinical studies, HG has been shown to improve outcomes in conditions such as sepsis, acute lung injury, hepatic injury, pancreatitis, cardiac arrest, traumatic injury, acute kidney injury, and brain injury

While this construct mimicked the first TCR signal upon CAR binding to its target antigen, they lacked the second signal necessary for efficient T-cell activation