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Salehi B, Martorell M, Arbiser JL, et al

There are several anticancer mechanisms that are p53-dependent, and phytochemicals also target p53-dependent reduction of cholesterol to reduce cancer risk ( The Role of p53 in Cholesterol Biosynthesis Cholesterol is synthesized via a cascade of enzymatic reactions within the cytosol and endoplasmic reticulum (ER), which are collectively known as the mevalonate (MVA) pathway