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Oxygen to be transported efficiently by erythrocytes depends on the presence of hemoglobin, a protein capable of binding oxygen through its central iron atom (128)

3.1 Mechanisms of ferroptosis in ischemic stroke Stroke, defined as an acute focal CNS injury caused by vascular events, results in neurological deficits

The Hippo pathway mediates ECs dysfunction and regulates angiogenesis by inducing EndMT via the transcription factor Smad2 (104)

A confirmed B12 deficiency is diagnosed through a blood test measuring serum B12 levels, along with tests for MMA and homocysteine, which become elevated in deficiency cases

MRS data processing MRS data were processed in MATLAB (Natick MA, USA) using the FID-A toolkit [50]

Closed-loop regenerative systems Closed-loop regenerative systems represent an advanced therapeutic model that integrates AI with real-time biological feedback to continuously optimize treatment interventions