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10.1159/000343113 [DOI] [PubMed] [Google Scholar] Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, Meucci G, Spina L, De Franchis R

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It is characterized by abnormal metabolism of the three major nutrients and suppression of mitochondrial oxidative phosphorylation (OXPHOS), which contributes to the onset and development of DKD

As individuals age, imbalances in gut bacteria lead to the release of proinflammatory microbial products due to compromised intestinal permeability ( Cell senescence Some scholars have proposed that cellular senescence may be the driver of skin aging

Additionally, this study underscores the need for clinical approaches that address both the toxicological aspects and modulation of the inflammatory response to improve patient outcomes

Fourth, understanding mechanisms of brain region-specific and age-dependent neuroprotection of the KD may reveal new insights into the regulation of neuronal survival pathways and the influence of bioenergetic pathways