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Klymchuk V

A., Dzierzewicz Z

Giuseppe et al

RNAi therapies: drugging the undruggable

Additionally, lactate can be converted to pyruvate intra-mitochondrially via mitochondrial lactate dehydrogenase (mLDH), rather than by the cytosolic isoform (cLDH), a reaction that initiates entry into the tricarboxylic acid (TCA) cycle and oxidative phosphorylation

A prospective study that measures GSH and its relationship with clinical features is crucial to assess the potential clinical utility of GSH in these pathological conditions