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2021), and migraines (Pardutz and Schoenen 2010)

PPE38, which is encoded by the region of difference 1 (RD1), interacts with the macrophage ubiquitin ligase (E3), Makorin Ring Finger Protein 1 (MKRN1), suppressing TRAF6-driven NF-kB and AP-1 signaling, cytokines (TNF-, IL-6), and NO production (Dou et al., 2022)

GSH is also a major antioxidant in the brain

Two transporters, Sodium Coupled Neutral Amino Acid Transporter 1 (SNAT1) and alanine-serine-cysteine transporter 2 (ASCT2), facilitate the absorption of amino acids like L-glutamine, L-alanine, and L-serine

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The modification with HA further enhances drug targeting to macrophages, ensuring more effective and safe treatment outcomes