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In recent years, the development of diagnostic reagents based on metabolomics has made significant progress, among which NMR and LC-MS technologies have become mainstream tools

systematically compared the transduction distribution of AAV1, 2, 5 and 8 serotypes in the knee joints of mice and found that different AAV serotypes showed different tissue tropisms in tissues such as synovium, cartilage and subsynovial bone (181)

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Dimethyl itaconate activates innate immune defenses, maintains inflammatory homeostasis, activates STAT3 and autophagy, and exhibits strong antimycobacterial properties in both macrophages and in vivo models [102]

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