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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

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FK866 was again administered at a low dose (0.5 mg/Kg) to aged mouse models over four weeks, leading to significant improvements in cognitive function and locomotor activity

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It leads to skin reactions, including rashes, hives, and other symptoms