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Eur J Pharmacol 651:1825

doi: 10.1039/D4RA06117A 85 StockleyR

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here, the positively charged side chain can form a hydrogen bond with the oxygen at C6 in inosine, as seen in the structures of Pfu SAHH (Lys59 in Fig

Collectively, the findings presented here support a unifying biological model in which transfusion-related iron overload induces a cascade of mitochondrial dysfunction, oxidative stress, endothelial activation, and inflammatory skewing

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