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Introduction Androgen-deprivation therapy (ADT) is considered a cornerstone treatment option for prostate cancer, the second leading cause of cancer mortality among North American men ( Despite the significant survival advantage it confers, ADT is associated with numerous adverse effects including increased risk for cardiovascular diseases, diabetes, sexual dysfunction, cognitive, and mood dysfunction, and sleep disturbance ( Metabolomic profiling refers to the comprehensive identification and quantification of endogenous or exogenous small-molecule metabolites ( Cancer-related fatigue is a clinical condition that likely encompasses a multitude of subcategories with different pathogenic mechanisms that lead to the same subjective experience ( Materials and Methods Study Participants This study was approved by the National Institutes of Health (NIH) Institutional Review Board

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It is undergoing assessment, particularly for its effectiveness in preventing and treating bacterial vaginosis, a condition marked by the deficiency of essential Lactobacillus flora crucial for host protection against infections

153 Jankowski et al

6.1 Biomarker discovery and validation Biomarkers are essential for diagnosing PD in its prodromal phase, tracking progression, and predicting treatment response