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Frontiers in Endocrinology, 11, 584

For persistent or atypical cramps, evaluate for metabolic (e.g., renal failure), endocrine (thyroid disorders), medicine-induced, and neuromuscular causes (Garrison et al., 2020)

The combination of these findings positioned NNMT as a candidate metabolic-disease and metabolic-aging research target, motivating development of selective small-molecule inhibitors including 5-Amino-1MQ