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The Company is advancing clinical programs, including trials of HG004 (granted ODD & RPDD by FDA) LIGHT trial (NCT06088992) and Phase 1/2 international, master-protocol STAR clinical trial (NCT05906953) for RPE65 -associated retinal disease, HG202 RNA-editing therapy SIGHT-I first-in-human trial (NCT06031727) and BRIGHT Phase 1 clinical trial (NCT06623279) for nAMD, HG204 RNA-editing therapy (granted ODD & RPDD by FDA and ODD by EMA) HERO trial (NCT06615206) for MECP2 duplication syndrome, and HG302 DNA-editing therapy (granted ODD & RPDD by FDA) first-in-human MUSCLE trial (NCT06594094) for DMD

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