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For cagrilintide , Phase 2 data has shown meaningful weight loss when used as monotherapy, and the CagriSema combination (cagrilintide plus semaglutide) has entered Phase 3 trials under the REDEFINE programme by Novo Nordisk

It does not require proof of efficacy in large trials the way we typically expect from drugs, but it facilitates prescribing, and that changes things a lot, because there wont be a black market anymore

Semaglutide has been tied to thyroid tumors, including medullary thyroid carcinoma, in animal research

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Furthermore, participants receiving Cagrilintide 4.5 mg achieved greater weight loss than those on liraglutide 3.0 mg demonstrated by a 10.8% vs