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Novel targets for Huntingtons disease in an mTOR-independent autophagy pathway

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Disclosures: Shubham Mehta: Nothing to Disclose, Dwarakanathan Vignesh: Nothing to Disclose, Sagnik Biswas: Nothing to Disclose, Shekhar Swaroop: Nothing to Disclose, Bodhisattya Roy Chaudhuri: Nothing to Disclose, Umang Arora: Nothing to Disclose, Arnav Aggarwal: Nothing to Disclose, Ayush Agarwal: Nothing to Disclose, Shalimar: Nothing to Disclose 691 EVALUATING THE IMPACT OF PRE-LIVER TRANSPLANT ACUTE-ON-CHRONIC LIVER FAILURE ON POST-LIVER TRANSPLANT PROGNOSIS IN PATIENTS WITH ALCOHOL-ASSOCIATED LIVER DISEASE David Lee 1 Ki Jung Lee 2 Sharmitha Yerneni 2 Kuntal Bhowmick 3 Youngjae Cha 1 Andrew Yi 1 KeeSeok Lee 2 Gregory Fan 2 Nathalie Urrunaga 1 , 1 University of Maryland School of Medicine, 2 Tufts School of Medicine, 3 Warren Alpert Medical School of Brown University Background: Alcohol- associated liver disease (ALD), the leading cause of chronic liver disease in the developed world, has created a growing need for liver transplantation (LT)

The combination of CBD with oxaliplatin has been shown to suppress eNOS phosphorylation and NO levels, triggering ROS-mediated autophagy and restoring tumor sensitivity to chemotherapy (Jeong et al

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