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Pharmaceutics 13:1753 Viard-Leveugle I, Gaide O, Jankovic D, Feldmeyer L, Kerl K, Pickard C, Roques S, Friedmann PS, Contassot E, French LE (2013) TNF- and IFN- are potential inducers of Fas-mediated keratinocyte apoptosis through activation of inducible nitric oxide synthase in toxic epidermal necrolysis

Supplementation with exogenous SP was able to reverse intestinal barrier disruption, and SP dose-dependently protected against intestinal inflammatory damage

Evidence indicates that uric acid is a useful scavenger of peroxyl radicals, hydroxyl radicals, and singlet oxygen (15, 97, 177, 367)

doi: 10.1016/j.crmeth.2021.100153

This redox guardian operates via three synergistic mechanisms: primarily by enhancing GSH synthesis under oxidative stress, secondly through maintaining GSH availability to preserve GPX4 activity (Chen et al., 2022), and finally via ferritin stabilization to suppress iron-driven lipid peroxidation