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IAV proteins differentially regulate pyroptosis

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A cell under chronic oxidative bombardment sustains protein damage, mitochondrial DNA mutations, and lipid peroxidation

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Also, the possibility exists that newly generated mitochondria are immediately damaged again by persistent factors that induce mitochondrial damage (e.g., oxidative stress), or that the process of actual biogenesis of mitochondria per se may be defective, resulting in generation of rather defective than functionally intact mitochondria