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Given the pharmacological limitations of existing PHGDH inhibitors, such as poor aqueous solubility and insufficient target specificity, nano-delivery systems have significantly improved tumor accumulation and therapeutic index through passive and active targeting strategies

In support of this observation, another study showed that mice treated with the HMOX1 inducer hemin previous to the induction of DSS colitis displayed reduced histological damage, which was associated to an increased expression of HMOX1

J Bras Nefrol

The therapeutic potential of this dual mechanism was validated in a cisplatin-induced acute kidney injury model, where selenomethionine administration significantly attenuated renal damage through ferroptosis inhibition

grafted the light-responsive azobenzene group on the surface of biodegradable MSNs, and -cyclodextrin-modified polymer as the cap agent