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(54), KRAS mutations can be detected in 38% of patients with colorectal cancer who were KRAS wild-type before the treatment, after 5-6 months of treatment with panitumumab

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Moreover, peroxynitrite has been implicated in the nitration of the EAAC1 neuronal transporters, reducing the cells ability to take up cysteine and inhibiting the intracellular neuronal production of the endogenous antioxidant glutathione, which can also lead to cell death due to the inability to counter intracellular oxidative stress (McElroy et al., 2017)

Author contributions GG: Conceptualization, Data curation, Methodology, Writing original draft, Writing review and editing

The cholinergic system, particularly the nicotinic acetylcholine receptors (nAChRs), plays a crucial role in motor control and cognition

An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy