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Ca 2+ -activated calcineurin dephosphorylates BAD, enhancing its proapoptotic activity

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doi: 10.1002/mrm.21041 15 Baltazar-DazT

Fontella FU, Pulrolnik V, Gassen E, Wannmacher CM, Klein AB, Wajner M, Dutra-Filho CS (2000) Propionic and L-methylmalonic acids induce oxidative stress in brain of young rats

This decline is due to neuronal loss, formation of neurofibrillary tangles (NFTs) and amyloid plaques, ultimately resulting in neuronal death and tissue atrophy (155)