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Science 303:20112015 Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W et al (2022) Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth

10.1038/s41467-021-20904-2 135 LiuL.HeJ.SunG.HuangN.BianZ.XuC.et al (2022)

Adenosine is known to play a role in pain transmission, and its deficiency may exacerbate pain symptoms in FM patients (Fais et al., 2013)

Other manifestations are related more to inflammatory consequences and/or structural disease and resultant organ dysfunction

Initiation at a late stage showed no effect on cognitive improvement