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(K) Effect of cardiomyocytes after transfection and exposure to HG on ECM synthesis in cardiac fibroblasts

These findings suggest the importance of identifying specific targets within the proteolytic pathways to help maintain degradative activities at optimal levels rather than bluntly activating or inhibiting them, to potentially mitigate cardiovascular risk in AF

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GowerBAChandler-LaneyPCOvalleFGoreeLLAzzizRDesmondRAet al

Doliska et al., 2004

For example, protein level signatures accompanying islet cell destruction or ensuing complications arising from the loss of glycaemic control might be discerned