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10.1021/acs.jmedchem.5b01641 J Med Chem

The humane endpoint was defined by a combination of clinical signs, including lethargy, hunched posture, and significant tumor volume

Next, we examined the localization of LDHA in the substantia nigra pars compacta (SNpc) using immunofluorescence co-staining and conducted colocalization analysis with markers for dopaminergic neurons, microglia, and astrocytes