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Research on ALS has been particularly informative in establishing this concept [294]

Circulating glutathione peroxidase and superoxide dismutase levels in patients with epilepsy: A meta-analysis

In this assay, cisplatin-treated plasmids are transfected into the cells, and the bioluminescence that is detected, owing to reactivation of luciferase expression, is directly related to the ability of cells to remove DNA damage

Therefore, the regulation of SCL7A11 is of great importance in ferroptosis resistance

Recent animal model studies have demonstrated that GLP-1 and its agonists exert notable neuroregulatory and neuroprotective effects (170)

For example, activation of the MAPK pathway can upregulate DNA repair factors such as XRCC1 and RAD51, thereby enhancing resistance to agents like mitomycin C [64]