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The ACR strongly, with good evidence, advises against combining methotrexate with any biologic other than a TNF blocker

NK cells are important in the defense against viral infection by killing infected cells and secreting of cytokines that hamper viral replication [28]

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Lancet Haematol 7:e737e745 Yigenoglu TN, Ata N, Altuntas F, Basc S, Dal MS, Korkmaz S, Namdaroglu S, Basturk A, Hacbekiroglu T, Dogu MH (2021) The outcome of COVID-19 in patients with hematological malignancy