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retrospectively evaluated liver biopsies in 29 patients (4.5% of those submitted to liver biopsy over an approximately five-year period at their institution) who had isolated, persistently raised, GGT 2 upper normal value [27]

Because TBK1 is an essential autophagy-related protein which phosphorylate autophagy receptors (i.e., autophagic adaptor optineurin) to regulate the recruitment of cargo into autophagosomes (Weidberg and Elazar, 2011), it is possible that ICP34.5 could also indirectly inhibit autophagy by modulating TBK1 signaling

By altering the mechanism of ROS via inhibiting or minimizing oxidative stress, the insights on animal models presented in this study offer future perspectives on the potential biomarkers and therapeutic options

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