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Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis

279 Suppressing p53 activity significantly improves senescence-like changes and insulin resistance in mice with T2D-like disease

38 , e19 (2021)

Third, it evaluates the effectiveness and feasibility of integrated management strategies, combining pharmacological treatments with non-clinical interventions