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These findings suggest that specific genetic mutations may contribute to the diminished ability of the immune system to effectively fight infections in elderly individuals, potentially compounding the challenges posed by immunosenescence

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The main link appears to be with the metabolic kynurenine pathway (KP) which interacts extensively with the immune system

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C., Calandra T., Jaton K., Giulieri S., Delaloye J., Opal S., Tracey K., van der Poll T., Pelfrene E., Lancet Infect

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Serine is required for synthesis of cystathione from homocysteine

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