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Ero1 can efficiently drive the oxidation of RNase A through PDI in the absence of GSH or GSSG, or even in the presence of excess GSH (Tu et al , 2000), indicating that oxidative protein folding proceeds through the direct transfer of oxidizing equivalents between PDI and Ero1

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Glutathione also plays a vital role in the recycling of other important antioxidants such as vitamins C and E, so their net protective effects are increased

Daniels and Hoseinifar, 2014)

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Furthermore, EV20K is more affordable and viable for the avoidance of AS than traditional EXOs (EV110K) (Mansouri-Kivaj et al., 2023)