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Some recent investigations have demonstrated that dexamethasone-loaded NPs can effectively cross the BBB and may further reduce neuroinflammation and safeguard the dopaminergic neurons in PD models

There are several known mechanisms that explain its neuro-protective effects: It plays a pivotal role in combating oxidative stress, reducing inflammation, and promoting mitochondrial function, and it is a precursor to glutathione

Blanco, R

Similarly, a systematic depletion of beneficial and anti-inflammatory taxa was observed in trauma exposed animals

Eur Food Res Technol

In CYB5R3-deficient conditions, MetHb builds up, glutathione (GSH) levels rise in response to oxidative stress, and RBCs display morphological changes such as microcytosis, acanthocytosis, and increased membrane fragility ( Due to the lack of mitochondria, RBCs depend on the pentose phosphate pathway (PPP) to produce reducing equivalents in the form of NADPH