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Under basal growth conditions (Figure 4A), HA + GSH-C4 significantly accelerated scratch closure at both 25 L and 50 L doses compared with control (p = 0.009 and p = 0.004, respectively), whereas the HA-only formulation produced a comparable effect only at 50 L (p = 0.022)

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albicans , machine learning and chemogenetic interaction analysis enabled screening of ~6,500 genes, expanding the GRACE (gene replacement and conditional expression) database by 866 entries and revealing 149 fungus-specific essential genes (Fu et al., 2021)

However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials

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