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Spiliotopoulos D, Caflisch A (2014) Molecular dynamics simulations of bromodomains reveal binding-site flexibility and multiple binding modes of the natural ligand acetyl-lysine

It plays a critical role in protecting cells by neutralizing free radicals , which are unstable molecules that contribute to oxidative stress and premature aging

[DOI] [PubMed] [Google Scholar] 76.Mouli V.P., Ananthakrishnan A.N

Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly

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ARA-290 has the strongest specific evidence for SFN, with human clinical trials demonstrating measurable nerve fiber regrowth in the cornea of SFN patients