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Positively charged and metal-doped CQDs show heightened oxidative and inflammatory responses, while negatively charged or hydrophilic CQDs remain generally safe

The core discrepancies may stem from two factors, first, distinct genetic backgrounds of mouse strains, with inherent differences in gut microbiota responses to disease between arthritis-susceptible and conventional models, and second, undefined Clostridium strains, which fail to rule out the possibility of pathogenic subtypes

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