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Presence of glutathione and GshR-Gpo couple is not indispensible for survival of LAB under oxidative stress but may work as an auxiliary system, apparently because of the other primary antioxidative systems active within the cells

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Since notochordal cells are highly synthetic, particularly for hydrophilic ECM molecules like aggrecan core protein and GAGs, either complete or gradual loss of this cell population in the IVD likely contributes to increased risk of degeneration over time (Risbud and Shapiro, 2011)