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They are involved in different cellular processes such as DNA replication, sulfate assimilation or response to oxidative stress

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178 In addition, the secreted Cu-binding glycoprotein SPARC (secreted protein acidic and cysteine-rich, also known as osteonectin) has been shown to modulate cellmatrix interactions and promote the invasion and metastasis of tumor cells

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Subsequently, they were stained with Annexin-V conjugated with FITC and Propidium iodide (PI) (Vazyme, A211-0) for 10 min at room temperature to detect apoptosis following the products instructions