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Senescent cells are known for their pro-inflammatory secretory phenotype, termed the Senescence-Associated Secretory Phenotype (SASP), which FOXO4-DRI effectively reduces, improving tissue function

Additionally, endosomal escape is a significant barrier as nucleic acids often become trapped in endosomes and degraded

It also reduces adverse effects and damage to healthy tissues (17)

Estrogen therapy may reduce the risk of heart disease in some women