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After initially discovering that group I metabotropic glutamate receptor signaling-dependent LTD is impaired in the hippocampus of FMR1 (Fragile X Mental Retardation gene 1) knock-out mice (Huber et al., 2002) and that the gene product of FMR1, FMRP (Fragile X Mental Retardation Protein), is a potent transcriptional repressor (Aschrafi et al., 2005

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