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The elevated PPP in cancer cells generates high NADPH levels to reduce ROS while simultaneously generating high levels of nucleotides for DNA synthesis and repair

Meune, C., Touze, E., Trinquart, L

VDAC2/3 knockdown inhibits erastin-induced ferroptosis, and erastin directly binds VDAC2 (117)

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Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation

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