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Sherman (*Co-First-authors) Ecteinascidin 743 (ET-743, Yondelis) is a clinically approved chemotherapeutic natural product isolated from the Caribbean mangrove tunicate Ecteinascidia turbinata

Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia

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While a substantial body of mechanistic evidence supports the role of circadian regulation, melatonin signaling, and redox balance in aging-related processes, translation to clinical outcomes remains an evolving field