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This mechanism is also relevant to minoxidil's effect on hair, though the pathways differ: minoxidil acts as a vasodilator that widens existing blood vessels, while VEGF upregulation promotes the formation of new ones

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19 Early studies: There were studies in the 1950s and the1960s that showed that oral vitamin B 12 could be absorbed by patients with pernicious anemia and could lead to resolution of the anemia