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The PUFAs in cell membranes contain multiple double hydrogen bonds that can react with hydroxyl radical, thereby triggering lipid peroxidation (Fig

2009;32:S31421

Given that abnormal activation of TLR7 has been clearly implicated in the pathogenesis of psoriasis, this post-translational modification may become a new target for psoriasis research by regulating the activity of the TLR7 signaling pathway (198)