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Essentially, proteins synthesized in the cytoplasm must unfold to pass through compact membrane channels to enter organelles, and the process of subsequent refolding requires the assistance of HSP70s

10.1007/s00586-008-0749-z 108 MasudaK.TakegamiK.AnH.KumanoF.ChibaK.AnderssonG

References Li, Y., Xie, H., Deng, Z., Wang, B., Tang, Y., Zhao, Z., Yuan, X., Zuo, Z., Xu, S., Zhang, Y., & Li, J

Figure 17: Diagram showing the haemolytic plaque assay developed by Jerne in 1962 (credit: Ivan Lefkovits)

Tretinoin reliably produces what dermatologists call retinoid dermatitis or the 'retinization' period during the first two to eight weeks: redness, flaking, dryness, stinging, and sometimes a temporary flare of breakouts

By binding to actin monomers (individual actin molecules), TB-500 controls their availability for polymerization into filaments