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Consistently with a role in fibroblast activation, an amelioration of tissue fibrosis was observed in TLR4 knockout in murine models of systemic sclerosis [131]

Consistent with this, many patients with chronic pain present with affective disturbances, such as depression (Liu et al., 2017)

Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells