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The action targets of the SGD have been identified to be involved in the regulation of various biological activities, including calcium- and cytokine-mediated signal transduction, calcium ion concentration and homeostasis, the cellular behavior of muscle and neuronal cells, inflammatory responses, and responses to chemicals, cytokines, drugs, and oxidative stress

Pharmacokinetic studies of several bioactive compounds have demonstrated limited oral bioavailability, rapid metabolism, extensive first-pass hepatic clearance, and low systemic exposure

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[5] GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation