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Previously, we demonstrated in a screening approach using FDA-approved drugs that the LIP/LAP ratio is druggable also apart from known mTORC1 inhibitors 59

In vitro, Mfn2 reconstitution enhanced mitochondrial membrane potential, mitigated oxidative stress, and promoted fusion-mediated mitochondrial function in cardiomyocytes exposed to high-glucose/HFD conditions, highlighting the regulation of Mfn2 as a promising therapeutic target in DbCM [69]

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Chen T, Tanaka M, Wang Y, Sha S, Furuya K, Chen L, et al

Monoclonal antibodies detect monocyte/macrophage activation and differentiation antigens and identify functionally distinct subpopulations of human rheumatoid synovial tissue macrophages