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4.1 Polymeric nanoparticles The development of smart nanoparticle delivery systems represents a transformative strategy to overcome the intrinsic limitations of curcumina potent natural compound with multifaceted anticancer propertiesincluding its extremely poor aqueous solubility, rapid systemic metabolism, and consequent low oral bioavailability

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Berghoff SA, Duking T, Spieth L, Winchenbach J, Stumpf SK, Gerndt N, Kusch K, Ruhwedel T, Mobius W, Saher G

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Furthermore, the clinical potential, key challenges and future prospects of these interventions were assessed