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4 Mechanism of neuroprotective action of hydrogen As the smallest molecule with exceptional tissue penetrability, H 2 exhibits unique antioxidant and anti-inflammatory properties, enabling it to effectively combat oxidative stress and inflammation

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Ferrostatin may also serve as the basis for future treatments for diseases characterized by tissue damage brought on by lipid peroxidation [14]

Glutathione protects mitochondrial function and maintains cellular energy balance

In contrast, the non-amyloidogenic pathway is characterized by more active -secretase-catalyzed cleavage (e.g., ADAM-10 and ADAM-17) of APP, releasing soluble APP from neuronal membranes into the interstitial space of the brain