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To obtain ratiometric images, the masks were applied to the background-subtracted images and the FP channel was divided by the SiR channel in a pixel-by-pixel manner within the ROIs

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Some of the possible factors that are abundant in CS are polyaromatic hydrocarbons (PAHs) that are inducers of cytochrome P450s and are well known sources of reactive oxygen species [28]

Activation of this system is a major source of ROS, which leads to NO depletion and endothelial dysfunction

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Thiazolidinediones are metabolized by the hepatic cytochrome P450 enzyme system